The circadian clock is an internal timekeeping system that aligns daily biological processes with environmental cycles, coordinating metabolism, sleep, and feeding patterns to maintain energy balance.
Disruptions to this clock are linked to metabolic disorders such as obesity and diabetes.
MORNING BODY eat SAME FOOD:
¹ enzyme activity: HIGH
² TEF: HIGH
³ gut community: efficient
⁴ autonomic state: sympathetic
⁵ insulin sensitivity: PEAK
EVENING BODY eat SAME FOOD:
¹ enzyme activity: LOW
² TEF: FRACTION
³ gut community: caloric-extracting
⁴ autonomic state: parasympathetic
⁵ insulin sensitivity: REDUCED
Metabolic outcome = Food x Body-state(t)
body state is a function of circadian time t
molecular circadian oscillator, period T= 24 hours.
BMAL1 (12°) →➡ CLOCK (3°) →➡ PER (6°) →➡ CRY 9°) back to BMAL1...
THE CLOCK IS NOT OPTIONAL
THE CLOCK IS NOT NEGOTIABLE
THE CLOCK IS THE METABOLISM
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